Loading...
Please wait, while we are loading the content...
Similar Documents
Quantitative assessment of cerebral hemodynamics using perfusion-weighted MRI in patients with major cerebral artery occlusive disease: comparison with positron emission tomography.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Endo, Hidehiko Inoue, Takashi Ogasawara, Kuniaki Fukuda, Takeshi Kanbara, Yoshiyuki Ogawa, Akira |
| Copyright Year | 2006 |
| Abstract | BACKGROUND AND PURPOSE Cerebrovascular reactivity (CVR) to acetazolamide is a key parameter in determining the severity of hemodynamic impairment in patients with major cerebral artery occlusive disease. Perfusion-weighted MRI (PW MRI) can measure the cerebral blood volume (CBV) as an indicator of hemodynamic impairment. CBV measured by PW MRI was compared with CVR measured by positron emission tomography (PET). METHODS Twelve normal subjects and 17 patients with major cerebral artery occlusive disease underwent PW MRI and PET. The images were coregistered with 3-dimensional spoiled gradient-recalled acquisition images. Quantitative PW MRI-CBV maps were generated using the indicator dilution method with arterial input function. One large cortical region of interest for each unilateral middle cerebral artery territory was determined on each image. PET-CVR was calculated by measuring cerebral blood flow before and after acetazolamide challenge. RESULTS A significant negative correlation was observed between PW MRI-CBV and PET-CVR (r=-0.713; P<0.0001). PW MRI-CBV higher than the mean +2 SD obtained in normal subjects (15.2 mL/100 g) was defined as elevated and PET-CVR lower than the mean -2 SD obtained in normal subjects (15.1%) was defined as reduced. Assuming the PET-CVR as the true determinant of hemodynamic impairment, PW MRI-CBV provided 80.0% sensitivity and 91.7% specificity, with 80.0% positive predictive value for detecting patients with reduced CVR. CONCLUSIONS The PW MRI-CBV method can simply and accurately identify patients with hemodynamic impairment without exposure to ionizing radiation. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/37/2/388.full.pdf |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/37/2/388.full.pdf?download=true |
| PubMed reference number | 16373637v1 |
| Volume Number | 37 |
| Issue Number | 2 |
| Journal | Stroke |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acetazolamide Carotid Endarterectomy Cerebral Arterial Diseases Cerebral Blood Volume Cerebral Infarction Cerebrovascular Circulation Cerebrovascular Disorders Cerebrovascular accident Cognition Disorders Gradient Hemodynamics Ionizing radiation PET/CT scan Patients Perfusion Magnetic Resonance Imaging Population Parameter Positive Predictive Value of Diagnostic Test Positron-Emission Tomography Positrons Structure of cerebral artery Structure of middle cerebral artery X-Ray Computed Tomography percent positive cells |
| Content Type | Text |
| Resource Type | Article |
