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Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM)

Content Provider	Scilit
Author	Zhang, Yan Gauthier, Susan A. Gupta, Ajay Comunale, Joseph Chiang, Gloria Chia-Yi Zhou, Dong Chen, Weiwei Giambrone, Ashley E. Zhu, Wenzhen Wang, Yi
Copyright Year	2016
Description	Journal: Journal of Magnetic Resonance Imaging (JMRI) To measure the longitudinal change in multiple sclerosis (MS) lesion susceptibility using quantitative susceptibility mapping (QSM). The study was approved by our Institutional Review Board. Longitudinal changes in quantitative susceptibility values of new enhanced-with-Gd MS lesions were measured at baseline magnetic resonance imaging (MRI) and on a follow-up MRI in 29 patients within 2 years using a 3D multiple echo gradient echo sequence on a 3T scanner. Paired t-test and the generalized estimating equations (GEE) model was used to analyze the longitudinal change. Lesion susceptibility values relative to normal-appearing white matter (NAWM) changed from 3.61 ± 6.11 ppb when enhanced-with-Gd at the baseline MRI to 20.42 ± 10.23 ppb when not-enhanced-with-Gd at the follow-up MRI (P < 0.001). MS lesion susceptibility value increases significantly as the lesion evolves from enhanced-with-Gd to not-enhanced-with-Gd, serving as a disease biomarker. J. Magn. Reson. Imaging 2016;44:426-432.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946979/pdf
Ending Page	432
Page Count	7
Starting Page	426
e-ISSN	15222586
DOI	10.1002/jmri.25144
Journal	Journal of Magnetic Resonance Imaging (JMRI)
Issue Number	2
Volume Number	44
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2016-01-22
Access Restriction	Open
Subject Keyword	Journal: Journal of Magnetic Resonance Imaging (JMRI) Radiology, Nuclear Medicine and Imaging Gadolinium Enhancement Longitudinal Change Magnetic Resonance Imaging Multiple Sclerosis Quantitative Susceptibility Mapping (qsm)
Content Type	Text
Resource Type	Article

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