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Quantitative susceptibility mapping (QSM) of white matter multiple sclerosis lesions: Interpreting positive susceptibility and the presence of iron
| Content Provider | Scilit |
|---|---|
| Author | Wisnieff, Cynthia Ramanan, Sriram Olesik, John Gauthier, Susan Wang, Yi Pitt, David |
| Copyright Year | 2014 |
| Description | Journal: Magnetic Resonance in Medicine Within multiple sclerosis (MS) lesions iron is present in chronically activated microglia. Thus, iron detection with MRI might provide a biomarker for chronic inflammation within lesions. Here, we examine contributions of iron and myelin to magnetic susceptibility of lesions on quantitative susceptibility mapping (QSM). Fixed MS brain tissue was assessed with MRI including gradient echo data, which was processed to generate field (phase), R2* and QSM. Five lesions were sectioned and evaluated by immunohistochemistry for presence of myelin, iron and microglia/macrophages. Two of the lesions had an elemental analysis for iron concentration mapping, and their phospholipid content was estimated from the difference in the iron and QSM data. Three of the five lesions had substantial iron deposition that was associated with microglia and positive susceptibility values. For the two lesions with elemental analysis, the QSM derived phospholipid content maps were consistent with myelin labeled histology. Positive susceptibility values with respect to water indicate the presence of iron in MS lesions, although both demyelination and iron deposition contribute to QSM. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333139/pdf |
| Ending Page | 570 |
| Page Count | 7 |
| Starting Page | 564 |
| e-ISSN | 15222594 |
| DOI | 10.1002/mrm.25420 |
| Journal | Magnetic Resonance in Medicine |
| Issue Number | 2 |
| Volume Number | 74 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2014-08-18 |
| Access Restriction | Open |
| Subject Keyword | Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging La-icp-ms Iron Quantification Ms Lesion Quantitative Susceptibility Mapping |
| Content Type | Text |
| Resource Type | Article |
