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Magnetic susceptibility contrast variations in multiple sclerosis lesions
| Content Provider | Scilit |
|---|---|
| Author | Li, Xu Harrison, Daniel M. Liu, Hongjun Jones, Craig K. Oh, Jiwon Calabresi, Peter A. van Zijl, Peter C. M. |
| Copyright Year | 2015 |
| Description | Journal: Journal of Magnetic Resonance Imaging (JMRI) Recent magnetic resonance imaging (MRI) studies have revealed heterogeneous magnetic susceptibility contrasts in multiple sclerosis (MS) lesions. Due to its sensitivity to disease-related iron and myelin changes, magnetic susceptibility-based measures may better reflect some pathological features of MS lesions. Hence, we sought to characterize MS lesions using combined R2* mapping and quantitative susceptibility mapping (QSM). In all, 306 MS lesions were selected from 24 MS patients who underwent 7T MRI. Maps of R2*, frequency, and quantitative susceptibility were calculated using acquired multiecho gradient echo (GRE) phase data. Lesions were categorized based on their image intensity or their anatomical locations. R2* and susceptibility values were quantified in each lesion based on manually drawn lesion masks and compared between lesion groups showing different contrast patterns. Correlations between R2* and susceptibility were also tested in these lesion groups. In 38% of selected lesions the frequency map did not show the same contrast pattern as the susceptibility map. While most lesions (93%) showed hypointensity on R2*, the susceptibility contrast in lesions varied, with 40% being isointense and 58% being hyperintense in the lesion core. Significant correlations (r = 0.31, P < 0.001) between R2* and susceptibility were found in susceptibility hyperintense lesions, but not in susceptibility isointense lesions. In addition, a higher proportion (74%) of periventricular lesions was found to be susceptibility hyperintense as compared to subcortical (53%) or juxtacortical (38%) lesions. Combining R2* and QSM is useful to characterize heterogeneity in MS lesions. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678033/pdf |
| Ending Page | 473 |
| Page Count | 11 |
| Starting Page | 463 |
| e-ISSN | 15222586 |
| DOI | 10.1002/jmri.24976 |
| Journal | Journal of Magnetic Resonance Imaging (JMRI) |
| Issue Number | 2 |
| Volume Number | 43 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2015-06-14 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Magnetic Resonance Imaging (JMRI) Radiology, Nuclear Medicine and Imaging Multiple Sclerosis Quantitative Susceptibility Mapping (qsm) |
| Content Type | Text |
| Resource Type | Article |
