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Methods for the computation of templates from quantitative magnetic susceptibility maps (QSM): Toward improved atlas- and voxel-based analyses (VBA)
| Content Provider | Scilit |
|---|---|
| Author | Hanspach, Jannis Dwyer, Michael G. Bergsland, Niels P. Feng, Xiang Hagemeier, Jesper Bertolino, Nicola Polak, Paul Reichenbach, Jürgen R. Zivadinov, Robert Schweser, Ferdinand |
| Copyright Year | 2017 |
| Description | Journal: Journal of Magnetic Resonance Imaging (JMRI) To develop and assess a method for the creation of templates for voxel-based analysis (VBA) and atlas-based approaches using quantitative magnetic susceptibility mapping (QSM). We studied four strategies for the creation of magnetic susceptibility brain templates, derived as successive extensions of the conventional template generation (CONV) based on only T1 -weighted (T1 w) images. One method that used only T1 w images involved a minor improvement of CONV (U-CONV). One method used only magnetic susceptibility maps as input for template generation (DIRECT), and the other two used a linear combination of susceptibility and T1 w images (HYBRID) and an algorithm that directly used both image modalities (MULTI), respectively. The strategies were evaluated in a group of N = 10 healthy human subjects and semiquantitatively assessed by three experienced raters. Template quality was compared statistically via worth estimates (WEs) obtained with a log-linear Bradley-Terry model. The overall quality of the templates was better for strategies including both susceptibility and T1 w contrast (MULTI: WE = 0.62; HYBRID: WE = 0.21), but the best method depended on the anatomical region of interest. While methods using only one modality resulted in lower WEs, lowest overall WEs were obtained when only T1 w images were used (DIRECT: WE = 0.12; U-CONV: WE = 0.05). Template generation strategies that employ only magnetic susceptibility contrast or both magnetic susceptibility and T1 w contrast produce templates with the highest quality. The optimal approach depends on the anatomical structures of interest. The established approach of using only T1 w images (CONV) results in reduced image quality compared to all other approaches studied. 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2017;46:1474-1484. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587351/pdf |
| Ending Page | 1484 |
| Page Count | 11 |
| Starting Page | 1474 |
| e-ISSN | 15222586 |
| DOI | 10.1002/jmri.25671 |
| Journal | Journal of Magnetic Resonance Imaging (JMRI) |
| Issue Number | 5 |
| Volume Number | 46 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2017-03-06 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Magnetic Resonance Imaging (JMRI) Radiology, Nuclear Medicine and Imaging T1-weighted Imaging Magnetic Resonance Imaging (mri) Quantitative Susceptibility Mapping (qsm) Voxel-based Analysis (vba) |
| Content Type | Text |
| Resource Type | Article |
