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Novel role of interleukin 7 in myelopoiesis: stimulation of primitive murine hematopoietic progenitor cells.
| Content Provider | Scilit |
|---|---|
| Author | Jacobsen, F. W. Veiby, O. P. Skjønsberg, C. Jacobsen, Sten Eirik Waelgaard |
| Copyright Year | 1993 |
| Description | Interleukin 7 (IL-7) has been demonstrated to be an important regulator of the growth of B and T cell precursors as well as mature T cells, whereas IL-7 has been reported to have no direct myeloproliferative effects. Here we show that IL-7 potently and directly enhances colony stimulating factor-induced myeloid colony formation from Lin-Sca-1+ murine bone marrow progenitor cells, increasing the cloning frequency up to ninefold and cell numbers up to 50-fold, without affecting their ability to differentiate along the myeloid lineages In contrast, IL-7 has no effect on proliferation of committed Lin- myeloid progenitors. Thus, in addition to its established lymphopoietic potential, this study implicates a novel role of IL-7 in early myelopoiesis. |
| Related Links | http://jem.rupress.org/content/178/5/1777.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191229/pdf https://rupress.org/jem/article-pdf/178/5/1777/495418/1777.pdf |
| Ending Page | 1782 |
| Page Count | 6 |
| Starting Page | 1777 |
| DOI | 10.1084/jem.178.5.1777 |
| Journal | The Journal of experimental medicine |
| Issue Number | 5 |
| Volume Number | 178 |
| Language | English |
| Publisher | Rockefeller University Press |
| Publisher Date | 1993-11-01 |
| Access Restriction | Open |
| Subject Keyword | Immunology Research and Experimental Medicine Hematopoietic Bone Marrow Lin Colony Progenitor Murine Myeloid Myelopoiesis Stimulating Differentiate Journal: The Journal of experimental medicine (Vol- 178, Issue- 5) |
| Content Type | Text |
