NDLI: CD4dull+ hematopoietic progenitor cells in murine bone marrow

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CD4dull+ hematopoietic progenitor cells in murine bone marrow

Content Provider	Scilit
Author	Onishi, M. Nagayoshi, K. Kitamura, K. Hirai, H. Takaku, F. Nakauchi, H.
Copyright Year	1993
Description	CD4+ cells comprise approximately 3% to 6% of murine bone marrow (BM) cells. The majority are CD4dull+, but there are two distinct sub populations: CD4 brightly positive Gr-1- cells (CD4hiGr-1-) and CD4+ Gr- 1+ cells (CD4loGr-1lo). CD4hiGr-1- cells are considered to be mature T cells by cell surface antigen expression and morphology. CD4loGr-1lo cells, which comprise approximately 0.6% of the BM cells, express small amount of B220 and Thy1 antigens. Interestingly, colony-forming units (CFU)-spleen and CFU-C are not enriched in this population. However, when injected into lethally irradiated mice, CD4loGr-1lo cells were shown to differentiate into T-cell, B-cell, and myelo-monocyte lineages when assayed 26 weeks after transplantation. Furthermore, donor-derived CD4loGr-1lo cells were present in the recipients' BM at least 16 weeks after transplantation. These observations suggest that murine CD4loGr- 1lo cells in BM have self-renewal capability and retain the ability to differentiate into at least three lineages in long-term hematopoiesis.
Related Links	https://ashpublications.org/blood/article-pdf/81/12/3217/610614/3217.pdf
Ending Page	3225
Page Count	9
Starting Page	3217
DOI	10.1182/blood.v81.12.3217.3217
Journal	Blood
Issue Number	12
Volume Number	81
Language	English
Publisher	American Society of Hematology
Publisher Date	1993-06-15
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Bone Marrow Antigen Differentiate Hematopoietic Murine Transplantation Cfu Cd4higr Journal: Blood (Vol- 119, Issue- 12)
Content Type	Text
Resource Type	Article

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