Synergistic interactions between interleukin-11 and interleukin-4 in support of proliferation of primitive hematopoietic progenitors of mice

Content Provider	Scilit
Author	Musashi, M. Clark, Sc Sudo, T. Urdal, Dl Ogawa, M.
Copyright Year	1991
Description	Interleukin-11 (IL-11) is a newly identified lymphohematopoietic cytokine originally derived from the primate bone marrow stromal cell line, PU-34. Separately, we reported that IL-11 augments IL-3-dependent proliferation of primitive murine hematopoietic progenitors in culture. We have now examined the synergistic interactions between IL-11 and IL- 4 in support of colony formation from marrow cells of mice treated 2 days before with 150 mg/kg 5-fluorouracil. Neither recombinant human IL- 11 nor murine IL-4 alone was effective in the support of colony formation. When the two factors were combined, there was major enhancement of colony formation, including that of multilineage colony- forming cells. Serial observations (mapping studies) of development of multipotential blast cell colonies indicated that the synergy between IL-11 and IL-4 is due in part to shortening of the dormant period of the stem cells, an effect very similar to that of IL-6 and granulocyte colony-stimulating factor. The combination of IL-11 and IL-4 may be useful in the stimulation of dormant hematopoietic stem cells in vivo.
Related Links	https://ashpublications.org/blood/article-pdf/78/6/1448/222740/1448.pdf
Ending Page	1451
Page Count	4
Starting Page	1448
DOI	10.1182/blood.v78.6.1448.bloodjournal7861448
Journal	Blood
Issue Number	6
Volume Number	78
Language	English
Publisher	American Society of Hematology
Publisher Date	1991-09-15
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Hematopoietic Bone Marrow Proliferation Cells Progenitors Colony Formation Murine Primitive Stimulating Journal: Blood (Vol- 88, Issue- 6)
Content Type	Text
Resource Type	Article