NDLI: Class Ia MHC-Deficient BALB/c Mice Generate CD8+ T Cell-Mediated Protective Immunity Against Listeria monocytogenes Infection

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Class Ia MHC-Deficient BALB/c Mice Generate CD8+ T Cell-Mediated Protective Immunity Against Listeria monocytogenes Infection

Content Provider	Scilit
Author	D’Orazio, Sarah E. F. Halme, Dina G. Ploegh, Hidde L. Starnbach, Michael N.
Copyright Year	2003
Description	$CD8^{+}$ T cells are required for protective immunity against intracellular pathogens such as Listeria monocytogenes. In this study, we used class Ia MHC-deficient mice, which have a severe reduction in circulating $CD8^{+}$ T cells, to determine the protective capacity of class Ib MHC-restricted T cells during L. monocytogenes infection. The $K^{b−/−}D^{b−/−}$ mutation was backcrossed onto a C.B10 (BALB/c congenic at H-2 locus with C57BL/10) background, because BALB/c mice are more susceptible to Listeria infection than other commonly studied mouse strains such as C57BL/6. C.B10 $K^{b−/−}D^{b−/−}$ mice immunized with a sublethal dose of L. monocytogenes were fully protected against a subsequent lethal infection. Adoptive transfer of Listeria-immune splenocyte subsets into naive $K^{b−/−}D^{b−/−}$ mice indicated that $CD8^{+}$ T cells were the major component of this protective immune response. A $CD8^{+}$ T cell line isolated from the spleen of a Listeria-infected class Ia MHC-deficient mouse was shown to specifically recognize Listeria-infected cells in vitro, as determined by IFN-γ secretion and cytotoxicity assays. Adoptive transfer of this T cell line alone resulted in significant protection against L. monocytogenes challenge. These results suggest that even a limited number of class Ib MHC-restricted T cells are sufficient to generate the rapid recall response required for protection against secondary infection with L. monocytogenes.
Ending Page	298
Page Count	8
Starting Page	291
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.171.1.291
Journal	The Journal of Immunology
Issue Number	1
Volume Number	171
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2003-07-01
Access Restriction	Open
Subject Keyword	Restricted T Cells Class Ib Mhc Mhc Restricted
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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