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Presence of clonal T cell populations in chronic B lymphocytic leukemia and smoldering myeloma.
| Content Provider | Scilit |
|---|---|
| Author | Wen, T. Mellstedt, H. Jondal, M. |
| Copyright Year | 1990 |
| Description | Clonality in the non-neoplastic T cell population was investigated in 21 patients with B cell chronic leukemic (B-CLL) or multiple myeloma (MM) by probing for TCR beta chain gene rearrangements using Southern blot analysis. In three patients with a benign form of B-CLL (stage 0), and in one patient with smoldering MM, evidence was found for predominant T cell clones. As cellular immunity against the malignant cells may be important in leukemia, the results are discussed in view of the potential role of T cell immunity in B-CLL and MM. |
| Related Links | http://jem.rupress.org/content/jem/171/3/659.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2187776/pdf http://jem.rupress.org/content/171/3/659.full.pdf |
| Ending Page | 666 |
| Page Count | 8 |
| Starting Page | 659 |
| DOI | 10.1084/jem.171.3.659 |
| Journal | The Journal of experimental medicine |
| Issue Number | 3 |
| Volume Number | 171 |
| Language | English |
| Publisher | Rockefeller University Press |
| Publisher Date | 1990-03-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Multiple Myeloma Malignant Lymphocytic Clonality Smoldering Neoplastic Leukemic Leukemia Blot Predominant Journal: The Journal of experimental medicine (Vol- 171, Issue- 3) |
| Content Type | Text |