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Molecular evidence for a single clonal origin in biphenotypic concomitant chronic lymphocytic leukemia and multiple myeloma
| Content Provider | Scilit |
|---|---|
| Author | Saltman, Dl Ross, Ja Banks, Re Ross, Fm Mackie, Mj |
| Copyright Year | 1989 |
| Description | To establish the clonal origin of a case of concomitant B-cell chronic lymphocytic leukemia (IgM kappa) and multiple myeloma (IGA lambda), we analyzed the immunoglobulin (Ig) gene rearrangements in the patient's blood and bone marrow. Despite the different isotypes, pretreatment investigation of the heavy chain gene (JH) revealed a germline fragment and two identical rearrangements in the blood and marrow. Both kappa and lambda light-chain genes were rearranged in the blood, suggesting peripheral blood lymphocyte involvement in the myeloma. Analysis of the Ig genes after chemotherapy demonstrated no change in the JH or CK rearrangements; however, the lambda genes were now in a germline configuration. Our results suggest that in this patient both chronic lymphocytic leukemia and myeloma originated from the same B-cell progenitor. |
| Related Links | https://ashpublications.org/blood/article-pdf/74/6/2062/218634/2062.pdf |
| Ending Page | 2065 |
| Page Count | 4 |
| Starting Page | 2062 |
| DOI | 10.1182/blood.v74.6.2062.bloodjournal7462062 |
| Journal | Blood |
| Issue Number | 6 |
| Volume Number | 74 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1989-11-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Multiple Myeloma Germline Bone Marrow Chronic Lymphocytic Leukemia Clonal Concomitant Journal: Blood (Vol- 88, Issue- 6) |
| Content Type | Text |
| Resource Type | Article |
