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Presence of clonal t cell populations in chronic b lymphocytic leukemia and smoldering myeloma.
| Content Provider | CiteSeerX |
|---|---|
| Author | Wen, Tao Mellstedt, Hakan Jondal, Mikael |
| Abstract | Chronic B lymphocytic leukemia (B-CLL) ' and multiple myeloma (MM) represent malignancies at different stages ofB cell differentiation. In B-CLL the majority of the cells have characteristics of immature B lymphocytes, whereas in MM the main part oftumor clone consists of end stage plasma cells (1-3). In both conditions, the cells of the malignant clones express surface Ig with unique antigen binding parts (idiotypes) (3-6). Both B-CLL and MM patients can be divided into different subgroups. In B-CLL a clinical staging system is used that vary from stage 0 to 4 (7, 8) and other factors such as the isotype of the surface Ig, the expression of growth factor receptors, and number of S-phase leukemic cells are clinically important (9-11). In MM, the term smoldering myeloma is used for a special type of benign MM (12, 13). In B-CLL there is evidence for abnormalities within the T and NK cell populations, (10, 14-17). These changes may be part ofa cellular response against the tumor cells. In this paper we address this question by analyzing the occurrence of clonal T cell populations in B-CLL and MM by probing for gene rearrangements representative of the a chain ofthe T cell receptor loci (TCR). The presence of such clonal T cells may indicate a host response directed against leukemia-related antigens or a special T-B cell interaction. We have found evidence for predominantT cell clones in 3/13 B-CLL patients and 1/8 MM patients, all in comparatively clinical benign stages. |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Mm Patient Different Stage Unique Antigen Binding Part Tumor Cell Different Subgroup Special Type Clinical Benign Stage Growth Factor Receptor End Stage Plasma Cell Gene Rearrangement S-phase Leukemic Cell Nk Cell Population B-cll Patient Clonal Cell Population Clinical Staging System Special T-b Cell Interaction Cellular Response Leukemia-related Antigen Benign Mm Chain Ofthe Cell Receptor Locus Clonal Cell Multiple Myeloma Host Response Surface Ig Main Part Oftumor Clone Represent Malignancy Cell Differentiation Chronic Lymphocytic Leukemia Malignant Clone Predominantt Cell Clone |
| Content Type | Text |
| Resource Type | Article |
