NDLI: Associated chronic lymphocytic leukemia and multiple myeloma: origin from a single clone

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Associated chronic lymphocytic leukemia and multiple myeloma: origin from a single clone

Content Provider	Scilit
Author	Fermand, Jp James, Jm Herait, P. Brouet, Jc
Copyright Year	1985
Description	We investigated the clonal relationship of malignant cells in a patient affected with both chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). CLL cells and malignant plasma cells synthesized IgG1 kappa and IgA kappa molecules, respectively; these monoclonal Ig shared idiotypic determinants, providing evidence that a single clonal disease occurred in this patient. Furthermore, when leukemic CLL cells were driven to differentiate in vitro to immunoblasts and plasma cells, a switch from IgG to IgA occurred in a significant percentage of cells that were double producers. These data suggest that, in some circumstances, CLL leukemic B cells may reach a more mature state, leading to the occurrence of clinical MM.
Related Links	https://ashpublications.org/blood/article-pdf/66/2/291/362529/291.pdf
Ending Page	293
Page Count	3
Starting Page	291
DOI	10.1182/blood.v66.2.291.bloodjournal662291
Journal	Blood
Issue Number	2
Volume Number	66
Language	English
Publisher	American Society of Hematology
Publisher Date	1985-08-01
Access Restriction	Open
Subject Keyword	Hematology Multiple Myeloma Leukemia Malignant Lymphocytic Cll Iga Clonal Kappa Differentiate Journal: Blood (Vol- 52, Issue- 2)
Content Type	Text
Resource Type	Article

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