NDLI: Dissolution from ordered mixtures: The effect of stirring rate and particle characteristics on the dissolution rate.

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Dissolution from ordered mixtures: The effect of stirring rate and particle characteristics on the dissolution rate.

Content Provider	Scilit
Author	Villiers, M. M. De Watt, J. G. Van Aer
Copyright Year	1989
Description	Journal: Drug Development and Industrial Pharmacy Different particle size fractions of three carriers were used to prepare ordered mixtures of frusemide. The dissolution of these mixtures were compared with a frusemide suspension and pure frusemide agglomerates by the USP XXI paddle method at three rotational speeds. The dissolution of mixtures containing a highly soluble carrier (sodium chloride) were comparable to the suspension depending on the particle size of the carrier. Insoluble carriers (dicalciumphosphatedihydrate and microcrystalline cellulose) increased the dissolution, but the enhancement depended on the rotational speed, the particle size and the density of the carrier.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03639048909040234
Ending Page	627
Page Count	7
Starting Page	621
ISSN	03639045
e-ISSN	15205762
DOI	10.3109/03639048909040234
Journal	Drug Development and Industrial Pharmacy
Issue Number	4
Volume Number	15
Language	English
Publisher	Informa UK Limited
Publisher Date	1989-01-01
Access Restriction	Open
Subject Keyword	Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Ordered Mixtures Particle Characteristics Stirring Rate Dissolution Rate Dissolution From Ordered
Content Type	Text
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

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