NDLI: The effect of 2-hydroxypropyl-ß-cyclodextrin on the solubility, stability and dissolution rate of famotidine

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The effect of 2-hydroxypropyl-ß-cyclodextrin on the solubility, stability and dissolution rate of famotidine

Content Provider	Scilit
Author	Islam, Mohammad S. Narurkar, Milind M.
Copyright Year	1991
Description	Journal: Drug Development and Industrial Pharmacy Famotidine was found to form an inclusion complex with 2-hydroxypropyl-ß-cyclodextrin (HPCD). Phase-solubility diagram was classified as type AL with a stability constant for complex formation (Kst) of 100.50 M1 at pH 7.4. Famotidine undergoes specific acid catalysis in strongly acidic solutions. Addition of HPCD to these solutions decreased the rate of drug degradation. The rate constant for degradation of complexed famotidine (kc) and Kst were estimated from the relationship between the observed rate constant for overall drug degradation (Kobs) and HPCD concentration. An increase in ionization of famotidine resulted in a decrease in the magnitude of Kst. The dissolution rate of the prepared complex was significantly greater than that of the pure drug.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03639049109043856
Ending Page	1239
Page Count	11
Starting Page	1229
ISSN	03639045
e-ISSN	15205762
DOI	10.3109/03639049109043856
Journal	Drug Development and Industrial Pharmacy
Issue Number	9
Volume Number	17
Language	English
Publisher	Informa UK Limited
Publisher Date	1991-01-01
Access Restriction	Open
Subject Keyword	Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Cyclodextrin Hydroxypropyl Dissolution Rate
Content Type	Text
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

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