NDLI: Hydrate Related Dissolution Characteristics of Norfloxacin

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Hydrate Related Dissolution Characteristics of Norfloxacin

Content Provider	Scilit
Author	Katdare, A. V. Bavitz, J. F.
Copyright Year	1984
Description	The effect of moisture and temperature on the physical and chemical stability of solid oral dosage forms of Norfloxacin was studied. The physical properties of the dosage form, i. e. breaking strength and disintegration time were not affected adversely. Dissolution characteristics of Norfloxacin tablets were found to be affected by humidity conditions. Tablets with poor dissolution characteristics were improved to satisfactory rates by exposure to 21–25°C/75% relative humidity. Exposure to lower humidities and higher temperatures adversely affected dissolution rates. Once favorable dissolution rates were attained, however, they remained unchanged in spite of dehydration of the tablets.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03639048409040783
Ending Page	807
Page Count	19
Starting Page	789
ISSN	03639045
e-ISSN	15205762
DOI	10.3109/03639048409040783
Journal	Drug Development and Industrial Pharmacy
Issue Number	5
Volume Number	10
Language	English
Publisher	Informa UK Limited
Publisher Date	1984-01-01
Access Restriction	Open
Subject Keyword	Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Norfloxacin Hydrate Related Dissolution Related Dissolution Characteristics
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

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