NDLI: The Effect of the Wet Granulation Process on Drug Dissolution

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The Effect of the Wet Granulation Process on Drug Dissolution

Content Provider	Scilit
Author	Unvala, Hoshang M. Schwartz, Joseph B. Schnaare, Roger L.
Copyright Year	1988
Description	Wet granulation can be an important processing step for pharmaceutical solid dosage forms. In this investigation emphasis was directed towards the influence of a “simple” wet granulation process on drug release from granules and their resulting tablets. Direct compression blends of the same materials were used as controls. Binary mixtures containing a 5% level of either theophylline, hydrochlorothiazide or chlorpheniramine maleate in microcrystalline cellulose or lactose were granulated with water. Experimentally, the powders were dry blended in a planetary mixer, wet granulated, and subsequently wet milled and dried. No dry milling step was included. Granule characterization consisted of particle size, density, porosity, compression and dissolution testing. Dissolution results varied with the drug, as expected, and dissolution at 10 minutes ranged from 35 to 95 % release. In general, however, the results indicate that dissolution from granules and the corresponding direct compression blend are similar. Although differences in compressibility were observed in the systems studied, granulation was not found to be detrimental to drug release.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03639048809151936
Ending Page	1349
Page Count	23
Starting Page	1327
ISSN	03639045
e-ISSN	15205762
DOI	10.3109/03639048809151936
Journal	Drug Development and Industrial Pharmacy
Issue Number	10
Volume Number	14
Language	English
Publisher	Informa UK Limited
Publisher Date	1988-01-01
Access Restriction	Open
Subject Keyword	Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Drug Dissolution Effect Wet Granulation Process
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

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