NDLI: Telomerase Activity

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Telomerase Activity

Content Provider	Scilit
Author	Gómez, Daniel Eduardo Gómez, Diego Luis Mengual Maloukh, Lina Armando, Romina Gabriela
Copyright Year	2017
Description	This chapter focuses on the structure and function of the telomere/telomerase complex, its regulation, the non telomeric activities of telomerase and diseases caused by alteration in the telomere/telomerase complex. Telomerase activity contains multiple factors that allow its regulation, including the expression of transcriptase component of telomerase (TERT) levels, post-transcriptional modifications, transportation and location and finally conformation and interactions with accessory proteins during assembly of the telomerase complex. TERT splice variants may be expressed in normal, pre- crisis and alternative lengthening of telomeres cells (ALT) that lack detectable telomerase activity. Interaction of telomerase with numerous telomere binding proteins (TBP) that may influence telomerase enzyme activity is considered another form of telomerase activity regulation. It is supposed that binding some of them to telomeres, therefore making it impossible for telomerase to access the chromosome ends, is an indirect way of regulation. Telomerase is essential for the long-term proliferation potential of stem cells and cancer cells, and for normal tissue renewal. Book Name: Telomeres, Diet and Human Disease
Related Links	https://api.taylorfrancis.com/content/chapters/edit/download?identifierName=doi&identifierValue=10.1201/9781315152431-2&type=chapterpdf
Ending Page	38
Page Count	14
Starting Page	25
DOI	10.1201/9781315152431-2
Language	English
Publisher	Informa UK Limited
Publisher Date	2017-08-30
Access Restriction	Open
Subject Keyword	Book Name: Telomeres, Diet and Human Disease Proteins Telomeres Conformation Telomere/telomerase Structure Function
Content Type	Text
Resource Type	Chapter

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