NDLI: Telomeres, telomerase and cellular immortalization

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Telomeres, telomerase and cellular immortalization

Content Provider	Scilit
Author	Jones, Christopher J.
Copyright Year	2021
Description	It is a well documented observation that normal human cells have a limited ability to proliferate in vitro (Hayflick, 1965). They then enter a state of viable growth arrest known as cellular or replicative senescence (Campisi, 1997; Faragher and Kipling, 1998). Replicative senescence arises as a consequence of chromosomal telomere shortening. This review discusses the structure of telomeres and the effects of abrogating the function of the proteins that bind them. Cancer cells overcome a series of barriers that limit proliferation and the significance of the widespread detection of telomerase in tumours is discussed. Telomerase is a ribonucleoprotein complex that synthesizes new telomeric DNA at chromosome ends. The key components of telomerase (a catalytic subunit and RNA template) and the phenotype of a telomerase knockout mouse are described. Finally, evidence is presented to show that prevention of telomere shortening, by forced expression of telomerase in some normal somatic cell types, is sufficient to allow avoidance of senescence. Book Name: Programmed Cell Death in Animals and Plants
Related Links	https://api.taylorfrancis.com/content/chapters/edit/download?identifierName=doi&identifierValue=10.1201/9781003076889-9&type=chapterpdf
Ending Page	148
Page Count	14
Starting Page	135
DOI	10.1201/9781003076889-9
Language	English
Publisher	Informa UK Limited
Publisher Date	2021-12-14
Access Restriction	Open
Subject Keyword	Book Name: Programmed Cell Death in Animals and Plants Telomerase Viable Telomere Cellular Somatic Proteins Structure Function Senescence Chromosomal
Content Type	Text
Resource Type	Chapter

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