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RNAi-mediated inhibition of PDGF-D leads to decreased cell growth, invasion and angiogenesis in the SGC-7901 gastric cancer xenograft model
| Content Provider | Scilit |
|---|---|
| Author | Zhao, Lin Zhang, Caiquan Liao, Gang Long, Jiegen |
| Copyright Year | 2010 |
| Description | Platelet-derived growth factor-D (PDGF-D) plays an important role in many types of human cancer. However, little is known about the function of this gene in gastric cancer. Here we demonstrated that PDGF-D is commonly overexpressed in gastric cancer. Silencing of PDGF-D using RNA interference significantly attenuated the proliferation and invasion potentials of SGC-7901 gastric cancer cells in which PDGF-D is overexpressed. Moreover, suppression of PDGF-D expression resulted in less activation of β-catenin and its downstream effector genes, cyclin D1 and matrix metalloproteinases, which are known to be involved in cell proliferation and invasion, respectively. Further, downregulation of PDGF-D remarkably reduced VEGF expression and secretion and proangiogenic activities of SGC-7901 cells in vitro. Most importantly, PDGF-D downregulation caused a significant decrease in tumor growth and angiogenesis in a SGC-7901 xenograft model. Together these findings suggest that PDGF-D is involved in the promotion of gastric cancer growth, invasion and angiogenesis, and RNAi-mediated silencing of this gene may thus offer a promising therapeutic strategy for PDGF-D-overexpressing gastric cancer. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cbt.9.1.10282?needAccess=true |
| Ending Page | 48 |
| Page Count | 7 |
| Starting Page | 42 |
| ISSN | 15384047 |
| e-ISSN | 15558576 |
| DOI | 10.4161/cbt.9.1.10282 |
| Journal | Cancer Biology & Therapy |
| Issue Number | 1 |
| Volume Number | 9 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2010-01-01 |
| Access Restriction | Open |
| Subject Keyword | Biochemistry and Molecular Biology Angiogenesis Invasion Cell Growth Pdgf-d Gastric Cancer Rna Interference |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pharmacology Molecular Medicine Oncology |
