RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells.

Content Provider	Europe PMC
Author	LIU, HUI LIANG, SHAOHUA YANG, XI JI, ZHAONING ZHAO, WENYING YE, XIAOBING RUI, JING
Copyright Year	2015
Abstract	An increasing body of evidence suggests that ribosomal proteins may have ribosome-independent functions and may be involved in various physiological and pathological processes. To examine the role of ribosomal protein L34 (RPL34) in cancer transformation, we assessed its expression in gastric cancer cell lines and found it highly expressed. We further used lentivirus-mediated small interfering RNAs (siRNAs) to knockdown RPL34 expression in the human gastric cancer cell line SGC-7901. RNA interference (RNAi)-mediated inhibition of RPL34 expression in SGC-7901 cells significantly suppressed cell proliferation, increased apoptosis and arrested cells in the S phase. The results of the present study suggest that RPL34 plays a critical role in cell proliferation, cell cycle distribution and apoptosis of human malignant gastric cells.
ISSN	1021335X
Journal	Oncology Reports
Volume Number	34
PubMed Central reference number	PMC4583519
Issue Number	5
PubMed reference number	26323242
e-ISSN	17912431
DOI	10.3892/or.2015.4219
Language	English
Publisher	D.A. Spandidos
Publisher Date	2015-08-21
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Liu et al.
Subject Keyword	RPL34 SGC-7901 proliferation apoptosis
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology