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Colony Stimulating Activities of GM-CSF, G-CSF and IL-3 on Blast Progenitors from Acute Myeloblastic Leukemia
| Content Provider | Scilit |
|---|---|
| Author | Motoji, Toshiko Takanashi, Minoko Masuda, Michihiko Nakayama, Keiko Oshimi, Kazuo Mizoguchi, Hideaki |
| Copyright Year | 1990 |
| Description | The colony stimulating activities (CSAs) of recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF), recombinant granulocyte colony-stimulating factor (rG-CSF) and recombinant interleukin-3 (rIL-3) on blast cells from various types of acute myeloblastic leukemia (AML) patients were studied using an in vitro blast colony assay. The stimulatory magnitude of rGM-CSF was highest in type M4 blasts but almost non-existent in type M1 blasts. Some preferential stimulatory action of rG-CSF was observed in type M2, M4 blasts and in overt leukemia in patients with refractory anemia with excess of blasts. On the other hand, the stimulatory activity of rIL-3 did not differ much with the AML subtype. Exposure to rGM-CSF, rG-CSF or rIL-3 did not alter the cellular phenotype or morphology of the leukemic blasts or the self-renewal capacity of blast progenitors. Simultaneous addition of rGM-CSF, rG-CSF and rIL-3, in various combinations, produced variable results and a simple additive effect was seen in 40% of the cases studied and either a significantly larger or smaller value in the remaining cases. Recombinant GM-CSF, rG-CSF and rIL-3 when added together did not reconstitute CSA of phytohemagglutinin-stimulated leukocyte-conditioned medium (PHA-LCM). |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/10428199009069294 |
| Ending Page | 414 |
| Page Count | 8 |
| Starting Page | 407 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428199009069294 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 6 |
| Volume Number | 2 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1990-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Pathology L-cfu Gm-csf G-csf Il-3 Aml Subtype |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Cancer Research Oncology |
