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The effects of three recombinant growth factors, IL-3, GM-CSF, and G- CSF, on the blast cells of acute myeloblastic leukemia maintained in short-term suspension culture
| Content Provider | Scilit |
|---|---|
| Author | Minden Miyauchi, J. Kelleher, Ca Yang, Yc Wong, Gg Clark, Sc Minkin, S. McCulloch, Ea |
| Copyright Year | 1987 |
| Description | The blast stem cells of acute myeloblastic leukemia (AML) respond in cell culture to growth factors by both self-renewal and terminal divisions. Both of these functions have been shown to be stimulated by the recombinant growth factors granulocyte-macrophage colony- stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF). In this paper, recombinant gibbon interleukin-3 (IL-3), homologous to human IL-3, was tested on blast cells and compared with the effects of GM-CSF, G-CSF, and medium conditioned by the bladder cell line 5637 (5637-CM). We found that IL-3 was an effective stimulator of blast renewal and terminal divisions. However, great patient-to-patient variation was found. A graphic method of presenting complex comparisons between growth factors is also included. |
| Related Links | https://ashpublications.org/blood/article-pdf/70/3/657/596496/657.pdf |
| Ending Page | 663 |
| Page Count | 7 |
| Starting Page | 657 |
| DOI | 10.1182/blood.v70.3.657.657 |
| Journal | Blood |
| Issue Number | 3 |
| Volume Number | 70 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1987-09-01 |
| Access Restriction | Open |
| Subject Keyword | Biotechnology and Microbiology Cell Culture Leukemia Colony Granulocyte Recombinant Gm Csf Myeloblastic Journal: Blood (Vol- 67, Issue- 3) |
| Content Type | Text |
| Resource Type | Article |
