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The effect of plasminogen activator inhibitor type 1 on apoptosis
| Content Provider | Scilit |
|---|---|
| Author | Chen, Yabing Sobel, Burton E. Schneider, David J. |
| Copyright Year | 2008 |
| Description | Summary Plasminogen activator inhibitor type-1 (PAI-1), an inhibitor of plasminogen activators, inhibits formation of plasmin and plasmin-mediated proteolysis. Apoptosis,or programmed cell death, is a potentially important phenomenon in mediating overall cell death. This review focuses on the influence of PAI-1 on apoptosis. Greater expression of PAI-1 has been associated with increased survival of cells and resistance to apoptosis. PAI-1 appears to influence apoptosis by decreasing cell adhesion (anoikis) as well as its effect on intracellular signaling. Mechanisms by which PAI-1 may render a cell resistant to apoptosis include its ability to inhibit generation of plasmin,its ability to inhibit caspase 3, and its ability to inhibit cell adhesion mediated by vitronectin. Inhibition of caspase 3 by PAI-1 may divert intracellular signalling from induction of apoptosis to induction of proliferation. |
| Related Links | http://pdfs.semanticscholar.org/3f9f/064cc39f4a2abac8f7483dab96c1ef36fe5a.pdf http://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH08-04-0234.pdf |
| Ending Page | 1040 |
| Page Count | 4 |
| Starting Page | 1037 |
| ISSN | 2567689X |
| DOI | 10.1160/th08-04-0234 |
| Journal | Thrombosis and Haemostasis |
| Issue Number | 12 |
| Volume Number | 100 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2008-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Thrombosis and Haemostasis Cell Death Plasminogen Activator |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
