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Plasminogen Activator Inhibitor 1: A New Prognostic Marker in Septic Shock
| Content Provider | Scilit |
|---|---|
| Author | Pralong, Gerard Calandra, Thierry Glausef, Michel-P Schellekens, Joop Verhoef, Jan Bachmann, Fedor |
| Editor | Kruithof, Egbert K. O. |
| Copyright Year | 1989 |
| Description | Summary: The prognostic value of plasminogen activator inhibitor type 1 (PAI-1) in septic shock was investigated in 52 patients with septic shock. The patients had significantly elevated serum PAI-1 levels with respect to the control group (p = 0.002). In patients not having a rapidly fatal underlying disease, PAI-1 was significantly higher in patients dying within a week after onset of shock than in survivors (median PAI-1: 900 and 307 ng/ml, respectively; p = 0.001). The analysis of the distribution of PAI-1 levels permitted retrospectively to determine a threshold level of PAI-1 which had prognostic significance. Mortality was 71% in patients with serum PAI-1 above 550 ng/ml, whereas only two patients (6%) having a PAI-1 below 550 ng/ml died within a week.Thus, in patients with septic shock, PAI-1 appears to have a strong predictive value as to mortality. This early marker may help the clinician in identifying a subgroup of patients particularly at risk. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1646614.pdf |
| Ending Page | 462 |
| Page Count | 4 |
| Starting Page | 459 |
| ISSN | 2567689X |
| DOI | 10.1055/s-0038-1646614 |
| Journal | Thrombosis and Haemostasis |
| Issue Number | 03 |
| Volume Number | 61 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1989-11-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Thrombosis and Haemostasis Plasminogen Activator Inhibitor Type 1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
