NDLI: Effect of CDP-choline on Hippocampal Acetylcholinesterase and $Na^{+},K^{+}$-ATPase in Adult and Aged Rats

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Effect of CDP-choline on Hippocampal Acetylcholinesterase and $Na^{+},K^{+}$-ATPase in Adult and Aged Rats

Content Provider	Scilit
Author	Plataras, Christos Angelogianni, Panagoula Tsakiris, Stylianos
Copyright Year	2003
Abstract	The aim of this study was to investigate the effect of different cytidine-5′-diphosphocholine (CDP-choline) concentrations (0.1-1 mm) on acetylcholinesterase (AChE), (Na⁺,K⁺)-ATPase and Mg²⁺-ATPase activities in homogenates of adult and aged rat hippocampi. Tissues were homogenised, centrifuged at 1000 × g for 10 min and in the supernatant, AChE activity and Na⁺,K⁺-ATPase and Mg²⁺-ATPase activities were determined according to Ellman’s method and Bowler’s and Tirri’s method, respectively. After an 1-3 h preincubation of the homogenised tissue with CDP-choline, a maximal AChE stimulation of about 25% for both adult and aged rats (p < 0.001) and a Na⁺,K⁺-ATPase activation of about 50% for adult rats (p < 0.001) and about 60% for aged rats (p < 0.001) were observed, while hippocampal Mg²⁺- ATPase activity was not influenced in either adult or aged animals. It is suggested that: CDP-choline can restore hippocampal AChE and Na⁺,K⁺-ATPase activities in the aged rat and thus it may play a role in improving memory performance which is impaired by aging and some neuronal disturbances.
Related Links	http://www.degruyter.com/downloadpdf/j/znc.2003.58.issue-3-4/znc-2003-3-423/znc-2003-3-423.xml
Ending Page	281
Page Count	5
Starting Page	277
e-ISSN	18657125
DOI	10.1515/znc-2003-3-423
Journal	Zeitschrift für Naturforschung C
Issue Number	3-4
Volume Number	58
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	2003-04-01
Access Restriction	Open
Subject Keyword	Zeitschrift Für Naturforschung C Gerontology Rat Hippocampal Acetylcholinesterase Rat Hippocampal Na+ K+-atpase Cdp-choline Journal: Zeitschrift für Naturforschung C, Vol- 58
Content Type	Text
Resource Type	Article

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