NDLI: Local suppression of Epstein-Barr virus (EBV)-specific cytotoxicity in biopsies of EBV-positive Hodgkin's disease

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Local suppression of Epstein-Barr virus (EBV)-specific cytotoxicity in biopsies of EBV-positive Hodgkin's disease

Content Provider	Scilit
Author	Frisan, T. Sjoberg, J. Dolcetti, R. Boiocchi, M. Re, V. De Carbone, A. Brautbar, C. Battat, S. Biberfeld, P. Eckman, M.
Copyright Year	1995
Description	Epstein-Barr virus (EBV)-positive Hodgkin's and Reed-Sternberg (HRS) cells express the virus-encoded latent membrane proteins LMP1 and LMP2 that could serve as rejection targets in Hodgkin's disease (HD). To examine whether EBV-triggered reactivities can be detected in the tumor, we have compared cytokine mRNA expression, cell phenotype, and cytotoxic activity in biopsies from 8 EBV-carrying and 6 EBV-HD patients. Neither the pattern of lymphokine production nor the cell phenotype of the in vivo-activated interleukin-2-responding populations provided a clear discrimination between EBV+ and EBV- cases. HLA class I-restricted EBV-specific cytotoxicity was shown in interleukin-2- dependent cultures from 3 of 3 EBV- tumors, whereas cultures from 6 of 6 EBV+ tumors were either noncytotoxic or exerted LAK-type cytotoxicity. EBV-specific cytotoxic T lymphocyte precursors were present in the blood of 1 patient carrying an EBV+ tumor. The results suggest that a tumor-associated suppression of EBV-specific T-cell responses may play an important role in the pathogenesis of EBV+ HD.
Related Links	https://ashpublications.org/blood/article-pdf/86/4/1493/617161/1493.pdf
Ending Page	1501
Page Count	9
Starting Page	1493
DOI	10.1182/blood.v86.4.1493.bloodjournal8641493
Journal	Blood
Issue Number	4
Volume Number	86
Language	English
Publisher	American Society of Hematology
Publisher Date	1995-08-15
Access Restriction	Open
Subject Keyword	Virology Virus Proteins Ebv Epstein Biopsies Hodgkin's Barr Specific Cytotoxicity Journal: Blood (Vol- 77, Issue- 4)
Content Type	Text
Resource Type	Article

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