NDLI: C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium

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C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium

Content Provider	Scilit
Author	Dentelli, Patrizia Rosso, Arturo Balsamo, Antonina Benedetto, Sofia Colmenares Zeoli, Annarita Pegoraro, Marco Camussi, Giovanni Pegoraro, Luigi Brizzi, Maria Felice
Copyright Year	2007
Description	We investigated the role of c-Kit and the membrane-bound ligand (mbKitL) in endothelial progenitor cell (EPC) recruitment by microvascular endothelial cells (ECs). We demonstrated that inflammatory activation induced the expression of the mbKitL on ECs both in vitro and in vivo, and that recruitment of EPCs depended on c-Kit/mbKitL interaction. Depletion of endogenous c-Kit or inhibition of c-Kit enzymatic activity by imatinib mesylate prevented adhesion of EPCs to activated ECs both in vitro and in vivo, indicating that a functional c-Kit on EPCs is essential. We also demonstrate that Akt was the downstream molecule regulating cell adhesion. A potential role of the c-Kit/mbKitL interaction in pathological settings is sustained by the expression of the mbKitL on ECs lining intraplaque neovessels. Thus, our results provide new insights into the mechanisms underlying EPC recruitment and the bases for novel strategies to hinder pathological angiogenesis.
Related Links	http://bloodjournal.hematologylibrary.org/content/109/10/4264.full.pdf
Ending Page	4271
Page Count	8
Starting Page	4264
DOI	10.1182/blood-2006-06-029603
Journal	Blood
Issue Number	10
Volume Number	109
Language	English
Publisher	American Society of Hematology
Publisher Date	2007-02-08
Access Restriction	Open
Subject Keyword	Cell Biology Research and Experimental Medicine Endothelial Progenitor Cell Cell Adhesion Angiogenesis Membrane Bound Ligand Mbkitl Ecs Journal: Blood (Vol- 114, Issue- 10)
Content Type	Text
Resource Type	Article

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