NDLI: CC chemokine ligand 20 partially controls adhesion of naive B cells to activated endothelial cells under shear stress

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CC chemokine ligand 20 partially controls adhesion of naive B cells to activated endothelial cells under shear stress

Content Provider	Scilit
Author	Meissner, Anja Zilles, Olaf Varona, Rosa Jozefowski, Katrin Ritter, Uwe Márquez, Gabriel Hallmann, Rupert Körner, Heinrich
Copyright Year	2003
Description	Chemokines are thought to control lymphocyte recruitment to the inflamed endothelium. To dissect chemokine-mediated adhesion, binding of ex vivo isolated splenocytes to tumor necrosis factor (TNF)–activated endothelial cells was analyzed under shear stress. We observed specific adhesion of naive follicular B cells, which could be blocked by pertussis toxin. This indicated a G protein–mediated binding and pointed at a contribution of chemokine receptors to B-cell adhesion. Analysis of chemokines expressed by TNF-activated endothelial cells showed that CC chemokine ligand 2 (CCL2), CCL17, and CCL20 were up-regulated. Only on follicular B cells was the cognate receptor for CCL20, CC chemokine receptor 6 (CCR6), expressed strongly, and a functional transmigration assay with CCR6-negative B cells demonstrated conclusively the sole signaling of CCL20 through CCR6. Desensitization of CCR6 on naive B cells with CCL20 resulted in receptor down-regulation and reduced B-cell adhesion. We conclude that CCL20 plays a vital role in B-cell adhesion to the inflamed endothelium.
Related Links	http://www.bloodjournal.org/content/bloodjournal/102/8/2724.full.pdf
Ending Page	2727
Page Count	4
Starting Page	2724
DOI	10.1182/blood-2003-01-0007
Journal	Blood
Issue Number	8
Volume Number	102
Language	English
Publisher	American Society of Hematology
Publisher Date	2003-10-15
Access Restriction	Open
Subject Keyword	Immunology Cell Adhesion Chemokine Inflamed Endothelium Endothelial Cells Desensitization Ccl20 Ccr6 Receptors To B Cell Journal: Blood (Vol- 104, Issue- 8)
Content Type	Text
Resource Type	Article

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