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Cutting Edge: Rapid In Vivo Killing by Memory CD8 T Cells
| Content Provider | Scilit |
|---|---|
| Author | Barber, Daniel L. Wherry, E. John Ahmed, Rafi |
| Copyright Year | 2003 |
| Description | In this study, we examined the cytotoxic activity of effector and memory CD8 T cells in vivo. At the peak of the CTL response following an acute lymphocytic choriomeningitis virus infection, effector CD8 T cells exhibited extremely rapid killing and started to eliminate adoptively transferred target cells within 15 min by a perforin-dependent mechanism. Although resting memory CD8 T cells are poorly cytolytic by in vitro$ ^{51}$Cr release assays, there was rapid elimination (within 1–4 h) of target cells after transfer into immune mice, and both $CD62L^{high}$ and $CD62L^{low}$ memory CD8 T cells were able to kill rapidly in vivo. Strikingly, when directly compared on a per cell basis, memory CD8 T cells were only slightly slower than effector cells in eliminating target cells. These data indicate that virus specific memory CD8 T cells can rapidly acquire cytotoxic function upon re-exposure to Ag and are much more efficient killers in vivo than previously appreciated. |
| Ending Page | 31 |
| Page Count | 5 |
| Starting Page | 27 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.171.1.27 |
| Journal | The Journal of Immunology |
| Issue Number | 1 |
| Volume Number | 171 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2003-07-01 |
| Access Restriction | Open |
| Subject Keyword | Memory Cd8 Cd8 T Cells |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
