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Cutting Edge: Increased Expression of Bcl-2 in Antigen-Specific Memory CD8+ T Cells
| Content Provider | Scilit |
|---|---|
| Author | Grayson, Jason M. Zajac, Allan J. Altman, John D. Ahmed, Rafi |
| Copyright Year | 2000 |
| Description | Bcl-2 plays a critical role in regulating cell survival and apoptosis. We examined Bcl-2 expression in virus-specific CD8 T cells during the expansion, death, and memory phases of the T cell response following infection of mice with lymphocytic choriomeningitis virus (LCMV). Naive CD8 T cells expressed a basal level of Bcl-2 that was down-regulated in effector CD8 T cells just before the death phase. Bcl-2 levels remained low during the death phase but surviving memory CD8 T cells expressed higher levels of Bcl-2 than naive cells. These changes were shown to occur in LCMV TCR transgenic cells as well as virus-specific CD8 T cells in C57BL/6 and BALB/c mice identified by MHC class I tetramers. In all instances, memory CD8 T cells expressed higher levels of Bcl-2, suggesting that increased Bcl-2 expression plays a role in the long-term maintenance of memory CD8 T cells in vivo. |
| Ending Page | 3954 |
| Page Count | 5 |
| Starting Page | 3950 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.164.8.3950 |
| Journal | The Journal of Immunology |
| Issue Number | 8 |
| Volume Number | 164 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2000-04-15 |
| Access Restriction | Open |
| Subject Keyword | Cells Just Before the Death Cells Expressed Memory Cd8 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
