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Cutting Edge: Protection by Antiviral Memory CD8 T Cells Requires Rapidly Produced Antigen in Large Amounts
| Content Provider | Scilit |
|---|---|
| Author | Remakus, Sanda Ma, Xueying Tang, Lingjuan Xu, Ren-Huan Knudson, Cory Melo-Silva, Carolina R. Rubio, Daniel Kuo, Yin-Ming Andrews, Andrew Sigal, Luis J. |
| Copyright Year | 2018 |
| Description | Numerous attempts to produce antiviral vaccines by harnessing memory CD8 T cells have failed. A barrier to progress is that we do not know what makes an Ag a viable target of protective CD8 T cell memory. We found that in mice susceptible to lethal mousepox (the mouse homolog of human smallpox), a dendritic cell vaccine that induced memory CD8 T cells fully protected mice when the infecting virus produced Ag in large quantities and with rapid kinetics. Protection did not occur when the Ag was produced in low amounts, even with rapid kinetics, and protection was only partial when the Ag was produced in large quantities but with slow kinetics. Hence, the amount and timing of Ag expression appear to be key determinants of memory CD8 T cell antiviral protective immunity. These findings may have important implications for vaccine design. |
| Ending Page | 3352 |
| Page Count | 6 |
| Starting Page | 3347 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.1701568 |
| Journal | The Journal of Immunology |
| Issue Number | 10 |
| Volume Number | 200 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2018-05-15 |
| Access Restriction | Open |
| Subject Keyword | Memory Cd8 Cd8 T Cell |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
