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Cutting Edge: Immediate RANTES Secretion by Resting Memory CD8 T Cells Following Antigenic Stimulation
| Content Provider | Scilit |
|---|---|
| Author | Walzer, Thierry Marçais, Antoine Saltel, Frédéric Bella, Chantal Jurdic, Pierre Marvel, Jacqueline |
| Copyright Year | 2003 |
| Description | The efficiency of CD8 memory response relies partially on the modification of cellular functional capacities. To identify effector functions that can be modified following priming, we have compared the chemokines produced by naive and memory CD8 T cells. Our results show that in contrast to naive cells, resting memory CD8 T cells contain high levels of RANTES mRNA. As a result, they have the capacity to rapidly secrete RANTES upon ex vivo antigenic stimulation. In contrast to that of IFN-γ, RANTES secretion is mainly due to the translation of the pre-existing mRNA. |
| Ending Page | 1619 |
| Page Count | 5 |
| Starting Page | 1615 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.170.4.1615 |
| Alternate Webpage(s) | http://www.jimmunol.org/content/170/4/1615.full.pdf |
| Journal | The Journal of Immunology |
| Issue Number | 4 |
| Volume Number | 170 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2003-02-15 |
| Access Restriction | Open |
| Subject Keyword | Antigenic Stimulation Secrete Rantes Memory Cd8 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
