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Cutting Edge: Attrition of Plasmodium-Specific Memory CD8 T Cells Results in Decreased Protection That Is Rescued by Booster Immunization
| Content Provider | Scilit |
|---|---|
| Author | Schmidt, Nathan W. Harty, John T. |
| Copyright Year | 2011 |
| Description | Sterile protection against infection with Plasmodium sporozoites requires high numbers of memory CD8 T cells. However, infections with unrelated pathogens, as may occur in areas endemic to malaria, can dramatically decrease pre-existing memory CD8 T cells. It remains unknown whether unrelated infections will compromise numbers of Plasmodium-specific memory CD8 T cells and thus limit the duration of antimalarial immunity generated by subunit vaccination. We show that P. berghei circumsporozoite-specific memory CD8 T cells underwent significant attrition in numbers in mice subjected to unrelated infections. Attrition was associated with preferential loss of effector memory CD8 T cells and reduced immunity to P. berghei sporozoite challenge. However, and of relevance to deployment of Plasmodium vaccines in areas endemic to malaria, attrition of memory CD8 T cells was reversed by booster immunization, which restored protection. These data suggest that regular booster immunizations may be required to sustain protective vaccine-induced Plasmodium-specific memory CD8 T cells in the face of attrition caused by unrelated infections. |
| Ending Page | 3840 |
| Page Count | 5 |
| Starting Page | 3836 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.1003949 |
| Alternate Webpage(s) | http://www.jimmunol.org/content/186/7/3836.full.pdf |
| Journal | The Journal of Immunology |
| Issue Number | 7 |
| Volume Number | 186 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2011-04-01 |
| Access Restriction | Open |
| Subject Keyword | Infectious Diseases Memory Cd8 Booster Immunization |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
