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Cutting Edge: Generation of Colitogenic Th17 CD4 T Cells Is Enhanced by IL-17+ γδ T Cells
| Content Provider | Scilit |
|---|---|
| Author | Do, Jeong-Su Visperas, Anabelle Dong, Chen Baldwin, William M. Min, Booki |
| Copyright Year | 2011 |
| Description | Th 17 cells have been implicated in the pathogenesis of colitis; however, a cellular mechanism by which colitogenic Th17 immunity arises in vivo remains unclear. In this study, we report that a subset of $IL-17^{+}$ γδ T cells plays a crucial role in enhancing in vivo Th17 differentiation and T cell-mediated colitis. $TCRβ^{−/−}$ mice were highly susceptible to T cell-mediated colitis, whereas $TCRβδ^{−/−}$ mice were resistant to the disease. Importantly, cotransfer of $IL-17^{+}$ but not of $IL-17^{−}$ γδ T cells with CD4 T cells was sufficient to enhance Th17 differentiation and induce full-blown colitis in $TCRβδ^{−/−}$ recipients. Collectively, our results provide a novel function of $IL-17^{+}$ γδ T cell subsets in supporting in vivo Th17 differentiation and possibly in fostering the development of intestinal inflammation. |
| Ending Page | 4550 |
| Page Count | 5 |
| Starting Page | 4546 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.1004021 |
| Alternate Webpage(s) | http://www.jimmunol.org/content/186/8/4546.full.pdf |
| Journal | The Journal of Immunology |
| Issue Number | 8 |
| Volume Number | 186 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2011-04-15 |
| Access Restriction | Open |
| Subject Keyword | Γδ T Cells Il-17 Th17 Cd4 T Cells |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
