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Cutting Edge: Identification of a Motile IL-17–Producing γδ T Cell Population in the Dermis
| Content Provider | Scilit |
|---|---|
| Author | Gray, Elizabeth E. Suzuki, Kazuhiro Cyster, Jason G. |
| Copyright Year | 2011 |
| Description | Dendritic epidermal T cells (DETCs) are a well-studied population of γδ T cells that play important roles in wound repair. In this study, we characterize a second major population of γδ T cells in the skin that is present in the dermis. In contrast to DETCs, these Vγ5-negative cells are $IL-7R^{hi}CCR6^{hi}$ retinoic acid-related orphan receptor $γt^{+}$ and are precommitted to IL-17 production. Dermal γδ T cells fail to reconstitute following irradiation and bone marrow transplantation unless the mice also receive a transfer of neonatal thymocytes. Real-time intravital imaging of $CXCR6^{GFP/+}$ mouse skin reveals dermal γδ T cells migrate at ∼4 μm/min, whereas DETCs are immobile. Like their counterparts in peripheral lymph nodes, dermal γδ T cells rapidly produce IL-17 following exposure to IL-1β plus IL-23. We have characterized a major population of skin γδ T cells and propose that these cells are a key source of IL-17 in the early hours after skin infection. |
| Ending Page | 6095 |
| Page Count | 5 |
| Starting Page | 6091 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.1100427 |
| Alternate Webpage(s) | http://www.jimmunol.org/content/186/11/6091.full.pdf |
| Journal | The Journal of Immunology |
| Issue Number | 11 |
| Volume Number | 186 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2011-06-01 |
| Access Restriction | Open |
| Subject Keyword | Bone Marrow Γδ T Cells Dermal Γδ Major Population |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
