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IL-27 Is a Key Regulator of IL-10 and IL-17 Production by Human CD4+ T Cells
| Content Provider | Scilit |
|---|---|
| Author | Murugaiyan, Gopal Mittal, Akanksha Lopez-Diego, Rocio Maier, Lisa M. Anderson, David E. Weiner, Howard L. |
| Copyright Year | 2009 |
| Description | Although the physiologic pathways that control regulatory T cells (Foxp3-expressing regulatory T cells, IL-10-secreting Tr1 cells) and Th17 cells in rodents have been defined, the factors that control these differentiation pathways in humans are not well understood. In this study, we show that IL-27 promotes the differentiation of IL-10-secreting Tr1 cells while inhibiting Th17 generation and molecules associated with Th17 function. Furthermore, IL-27 inhibits IL-17-polarizing cytokines on dendritic cells, which in turn decrease IL-17 secretion from T cells. Our results demonstrate that IL-27 plays a key role in human T cells by promoting IL-10-secreting Tr1 cells and inhibiting Th17 cells and thus provides a dual regulatory mechanism to control autoimmunity and tissue inflammation. |
| Ending Page | 2443 |
| Page Count | 9 |
| Starting Page | 2435 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.0900568 |
| Journal | The Journal of Immunology |
| Issue Number | 4 |
| Volume Number | 183 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2009-08-15 |
| Access Restriction | Open |
| Subject Keyword | Th17 Cells Inhibiting Th17 Secreting Tr1 Cells |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
