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IL-17 Production Is Dominated by γδ T Cells rather than CD4 T Cells during Mycobacterium tuberculosis Infection
| Content Provider | Scilit |
|---|---|
| Author | JoAnne, L. Flynn Lockhart, Euan Green, Angela M. |
| Copyright Year | 2006 |
| Description | IL-17 is a cytokine produced by T cells in response to IL-23. Recent data support a new subset of CD4 Th cells distinct from Th1 or Th2 cells that produce IL-17 and may contribute to inflammation. In this study, we demonstrate that, in naive mice, as well as during Mycobacterium tuberculosis infection, IL-17 production is primarily from γδ T cells and other non-CD4+CD8+ cells, rather than CD4 T cells. The production of IL-17 by these cells is stimulated by IL-23 alone, and strongly induced by the cytokines, including IL-23, produced by M. tuberculosis-infected dendritic cells. IL-23 is present in the lungs early in infection and the IL-17-producing cells, such as γδ T cells, may represent a central innate protective response to pulmonary infection. |
| Ending Page | 4669 |
| Page Count | 8 |
| Starting Page | 4662 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.177.7.4662 |
| Journal | The Journal of Immunology |
| Issue Number | 7 |
| Volume Number | 177 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2006-10-01 |
| Access Restriction | Open |
| Subject Keyword | Γδ T Cells Produced By T Cells |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
