NDLI: MiR-199a-5p Inhibits the Growth and Metastasis of Colorectal Cancer Cells by Targeting ROCK1

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MiR-199a-5p Inhibits the Growth and Metastasis of Colorectal Cancer Cells by Targeting ROCK1

Content Provider	SAGE Publishing
Author	Zhu, Qian Dong Zhou, Qing Qing Dong, Lemei Huang, Zhiming Wu, Fang Deng, Xia
Copyright Year	2018
Abstract	Mounting evidence indicates that microRNAs play important roles in the development of various cancers. Aberrant expression of microRNA-199a-5p has been frequently reported in cancer studies; however, the mechanistic details of the role of microRNA-199a-5p in colorectal cancer still remain unclear. Our study aimed to explore the role of microRNA-199a-5p in colorectal cancer cells by targeting Rho-associated coiled coil-containing protein kinase 1. Here, we showed that microRNA-199a-5p was significantly downregulated in colorectal cancer cell lines and tissue samples and was associated with a poor prognostic phenotype. MicroRNA-199a-5p suppressed colorectal cancer cell proliferation, migration, and invasion and induced cell apoptosis. Moreover, we identified Rho-associated coiled coil-containing protein kinase 1 as the direct target of microRNA-199a-5p using luciferase and Western blot assays. Importantly, Rho-associated coiled coil-containing protein kinase 1 overexpression rescued the microRNA-199a-5p-induced suppression of proliferation, migration, and invasion of colorectal cancer cells. Furthermore, the overexpression of microRNA-199a-5p inhibited tumor growth and metastasis by inactivating the phosphoinositide 3-kinase/AKT and Janus kinase 1/signal transducing activator of transcription signaling pathways through downregulation of Rho-associated coiled coil-containing protein kinase 1. Altogether, microRNA-199a-5p/Rho-associated coiled coil-containing protein kinase 1 may be a potential therapeutic target for colorectal cancer therapy.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/1533034618775509?download=true
ISSN	15330346
Volume Number	17
Journal	Technology in Cancer Research & Treatment (TCT)
e-ISSN	15330338
DOI	10.1177/1533034618775509
Language	English
Publisher	Sage Publications CA
Publisher Date	2018-05-28
Publisher Place	Los Angeles
Access Restriction	Open
Rights Holder	© The Author(s) 2018
Subject Keyword	colorectal cancer miR-199a-5p progression cell apoptosis ROCK1
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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