NDLI: Influence of red blood cells on nanoparticle targeted delivery in microcirculation

Please wait, while we are loading the content...

Dissipative particle dynamics simulation of the micellization–demicellization process and micellar shuttle of a diblock copolymer in a biphasic system (water/ionic-liquid)

Field- and concentration-dependence of electrostatics in non-polar colloidal asphaltene suspensions

Length-dependent translocation of polymers through nanochannels

Structure of DNA-functionalized dendrimer nanoparticles

Aggregation behavior of two separate polymers confined between two membranes

Understanding the thermo-sensitivity of crystalline colloidal arrays formed by poly(styrene-co-N-isopropylacrylamide) core–shell microspheres

Notable formation of a cubic phase from small bent-angle molecules based on the 1,7-naphthalene central core and alkylthio tails

Electrophoretic adhesion of biodegradable hydrogels through the intermediary of oppositely charged polyelectrolytes

Particle nanosomes with tailored silhouettes

Influence of red blood cells on nanoparticle targeted delivery in microcirculation

High resolution magic angle spinning NMR investigation of silk protein structure within major ampullate glands of orb weaving spiders

Nanocomposite silica surfactant microcapsules by evaporation induced self assembly: tuning the morphological buckling by modifying viscosity and surface charge

Photocrosslinkable chitosan based hydrogels for neural tissue engineering

Electrophoretic stretching of tethered polymer chains by travelling-wave electric fields: tunable stretching, expedited coil–stretch transition, and a new paradigm of dynamic molecular probing

How properties of interacting depletant particles control aggregation of hard-sphere colloids

Temperature and hydration dependence of low-frequency spectra of poly-l-glutamic acid with different secondary structures studied by terahertz time-domain spectroscopy

Biomimetic membrane rafts stably supported on unmodified gold

Low–temperature biaxial nematic from rod and disc mesogen mixture

The mobilities of micro- and nano-particles at interfaces of nematic liquid crystals

Activation and stabilization of a lipase nanogel using GMA for acryloylation

Back cover

Soft Matter Vol - 8 Issue - 5

Influence of red blood cells on nanoparticle targeted delivery in microcirculation

Content Provider	Royal Society of Chemistry (RSC)
Author	Liu, Yaling Thomas, Antony Tan, Jifu
Copyright Year	2012
Abstract	Multifunctional nanomedicine holds considerable promise as the next generation of medicine that allows for targeted therapy with minimal toxicity. Most current studies on nanoparticle (NP) drug delivery consider a Newtonian fluid with suspending NPs. However, blood is a complex biological fluid composed of deformable cells, proteins, platelets, and plasma. For blood flow in capillaries, arterioles and venules, the particulate nature of the blood needs to be considered in the delivery process. The existence of the cell-free-layer and NP–cell interaction will largely influence both the dispersion and binding rates, thus impact targeted delivery efficacy. In this paper, a particle–cell hybrid model is developed to model NP transport, dispersion, and binding dynamics in blood suspension. The motion and deformation of red blood cells (RBCs) is captured through the Immersed Finite Element Method. The motion and adhesion of individual NPs are tracked through Brownian adhesion dynamics. A mapping algorithm and an interaction potential function are introduced to consider the cell–particle collision. NP dispersion and binding rates are derived from the developed model under various rheology conditions. The influence of red blood cells, vascular flow rate, and particle size on NP distribution and delivery efficacy is characterized. A non-uniform NP distribution profile with higher particle concentration near the vessel wall is observed. Such distribution leads to over 50% higher particle binding rate compared to the case without RBC considered. The tumbling motion of RBCs in the core region of the capillary is found to enhance NP dispersion, with dispersion rate increasing as shear rate increases. Results from this study contribute to the fundamental understanding and knowledge on how the particulate nature of blood influences NP delivery, which will provide mechanistic insights on the nanomedicine design for targeted drug delivery applications.
Starting Page	1934
Ending Page	1946
Page Count	13
File Format	HTM / HTML PDF
ISSN	1744683X
Volume Number	8
Issue Number	6
Journal	Soft Matter
DOI	10.1039/c2sm06391c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Targeted therapy Nanoparticle Arteriole Rheology Dispersion relation Drug delivery Algorithm Blood plasma Shear rate Finite element method RBC Capillary Newtonian fluid Nanomedicine
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Influence of Red Blood Cells on Nanoparticle Targeted Delivery in Microcirculation

A multiphase model for Nanoparticle delivery in microcirculation

Red blood cell (RBC) aggregation and its influence on non-Newtonian nature of blood in microvasculature

shear stress in backward-facing step flow of a red blood cell suspension. Biorheology (1998)

Rheology of red blood cell aggregation by computer simulation

Effects of non-newtonian properties of blood flow on magnetic nanoparticle targeted drug delivery

Study of capillary blood flow properties at low shear rates through non newtonian fluid models

Hemodynamic Functionality of Transfused Red Blood Cells in the Microcirculation of Blood Recipients

Role of erythrocyte deformability during capillary wetting (2005).

Influence of red blood cells on nanoparticle targeted delivery in microcirculation

Similar Documents

Influence of Red Blood Cells on Nanoparticle Targeted Delivery in Microcirculation

A multiphase model for Nanoparticle delivery in microcirculation

Red blood cell (RBC) aggregation and its influence on non-Newtonian nature of blood in microvasculature

shear stress in backward-facing step flow of a red blood cell suspension. Biorheology (1998)

Rheology of red blood cell aggregation by computer simulation

Effects of non-newtonian properties of blood flow on magnetic nanoparticle targeted drug delivery

Study of capillary blood flow properties at low shear rates through non newtonian fluid models

Hemodynamic Functionality of Transfused Red Blood Cells in the Microcirculation of Blood Recipients

Role of erythrocyte deformability during capillary wetting (2005).

Influence of red blood cells on nanoparticle targeted delivery in microcirculation