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Anticancer drug delivery systems based on noncovalent interactions between carbon nanotubes and linear–dendritic copolymers

Back cover

Soft Matter Vol - 7 Issue - 7

Soft Matter Vol - 7 Issue - 6

Soft Matter Vol - 7 Issue - 5

Soft Matter Vol - 7 Issue - 4

Soft Matter Vol - 7 Issue - 3

Anticancer drug delivery systems based on noncovalent interactions between carbon nanotubes and linear–dendritic copolymers

Content Provider	Royal Society of Chemistry (RSC)
Author	Ashiri, Masoumeh Adeli, Mohsen Kabiri, Roya Bavadi, Masoumeh Hakimpoor, Farahman
Copyright Year	2011
Abstract	Hybrid nanomaterial-based drug delivery systems (HNDDSs) consisting of carbon nanotubes and linear–dendritic copolymers linked to anticancer drugs were synthesized and characterized. Polycitric acid–polyethylene glycol–polycitric acid (PCA–PEG–PCA) linear–dendritic copolymers were used to solubilize and functionalize multi-walled carbon nanotubes (MWCNTs) by noncovalent interactions. There are two key features of HNDDSs: (a) functionalized MWCNTs as a biocompatible platform for the delivery of therapeutic agents and diagnostics, (b) PCA–PEG–PCA linear–dendritic copolymers as water soluble, biocompatible and highly functional hybrid materials with a linear PEG block and two dendritic PCA blocks that improve the solubility and functionality of MWCNTs respectively. In this work, cisplatin (cis-diamminedichloroplatinum (CDDP)—a platinum-based chemotherapy drug) was conjugated to the carboxyl functional groups of the dendritic blocks of PCA–PEG–PCA linear–dendritic copolymers and then the prodrugs interacted with the MWCNTs noncovalently and HNDDSs were obtained. To prove the efficacy of the synthesized HNDDSs, they were subjected to endocytosis and released CDDP molecules inside murine colon adenocarcinoma tumor C26 cancer cells. Then it was proved that HNDDSs are able to kill cancer cells effectively. Release of the anticancer drug from HNDDSs was also investigated.
Starting Page	4062
Ending Page	4070
Page Count	9
File Format	HTM / HTML PDF
ISSN	1744683X
Volume Number	7
Issue Number	8
Journal	Soft Matter
DOI	10.1039/c0sm01550d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Carbon nanotube Adenocarcinoma Chemotherapy Endocytosis Carboxylic acid Colorectal cancer Biocompatibility Drug delivery Cisplatin PCA Cancer
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics

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