NDLI: Polyamidoamine and polyglycerol; their linear, dendritic and linear–dendritic architectures as anticancer drug delivery systems

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Journal of Materials Chemistry B Vol - 3 Issue - 9

Journal of Materials Chemistry B Vol - 3 Issue - 8

Journal of Materials Chemistry B Vol - 3 Issue - 7

Journal of Materials Chemistry B Vol - 3 Issue - 6

Journal of Materials Chemistry B Vol - 3 Issue - 5

Journal of Materials Chemistry B Vol -2

Journal of Materials Chemistry B Vol -1

Polyamidoamine and polyglycerol; their linear, dendritic and linear–dendritic architectures as anticancer drug delivery systems

Content Provider	Royal Society of Chemistry (RSC)
Author	Kharat, Ali Nemati Mohammadifar, Ehsan Adeli, Mohsen
Copyright Year	2015
Abstract	Despite extensive investigations in the field of cancer diagnosis and therapy in recent decades, cancer is still the major cause of morbidity and mortality all over the world. Recently, with the advancement of nanotechnology, the design and preparation of efficient nano-sized structures with the potential for diagnosis and treatment of cancer have been proposed. Among the different types of nano-sized materials, biocompatible polymers seem to be innovative tools with huge potential for cancer treatment. Advances in polymer chemistry and the application of various organic reactions have enabled the design and tailoring of multifunctional polymeric platforms with controllable architectures, with the ability to carry anticancer drugs, labelling probes and targeting agents simultaneously. This review covers the latest advances in the conjugation of the most studied chemotherapeutics (such as doxorubicin, paclitaxel, methotrexate, fluorouracil and cisplatin) to common dendritic polymers, including polyamidoamine dendrimers and hyperbranched polyglycerols (PGs) and their linear analogues, producing fatal weapons against tumors, with a focus on their cytotoxicity, biodistribution and biodegradability.
Starting Page	3896
Ending Page	3921
Page Count	26
File Format	HTM / HTML PDF
ISSN	2050750X
Volume Number	3
Issue Number	19
Journal	Journal of Materials Chemistry B
DOI	10.1039/c4tb02133a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Cancer Disease Nanotechnology Biocompatibility Polymer chemistry Doxorubicin Paclitaxel Methotrexate Fluorouracil Cisplatin Cytotoxicity
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Materials Science Biomedical Engineering

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