NDLI: A structure–gelation ability study in a short peptide-based ‘Super Hydrogelator’ system

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A structure–gelation ability study in a short peptide-based ‘Super Hydrogelator’ system

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Soft Matter Vol - 7 Issue - 7

Soft Matter Vol - 7 Issue - 6

Soft Matter Vol - 7 Issue - 5

Soft Matter Vol - 7 Issue - 4

Soft Matter Vol - 7 Issue - 3

A structure–gelation ability study in a short peptide-based ‘Super Hydrogelator’ system

Content Provider	Royal Society of Chemistry (RSC)
Author	Wang, Huaimin Yang, Zhimou Yang, Cuihong Tan, Ming Kong, Deling Wang, Ling
Copyright Year	2011
Abstract	The development of small molecules that can efficiently gel water is of great interest for researchers in the field of self-assembly. We recently found that a short peptide-based molecule (Nap-GFFpY-OMe) could form hydrogels at a minimum gelation concentration of 0.01 wt% after enzymatic conversion, which was the most efficient small molecular hydrogelator reported up to now. In order to study the relationship between the chemical structure and the gelation ability for these short peptide-based gelators, we designed and synthesized a small library of compounds with similar chemical structures to Nap-GFFpY-OMe. They have different capping groups for the amine on glycine (G), different numbers of glycines, different numbers of phenylalanines (F), and different groups at the C-terminus of the peptides. Based on the results, we concluded that the compounds were ‘super gelators’ when their amine capping group was naphthalene, the number of G residues was odd (one and three), the number of F residues was two, and the C-terminus of the peptide was a methyl ester. We found that 10 compounds within the library could form hydrogels and the hydrogels were characterized by rheology, transmission electron microscopy (TEM), and fluorescence spectroscopy. The cytotoxicity of all the precursors of the gelators were also evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and we found that three precursors possessed obviously bigger IC50 values than their corresponding minimum gelation concentrations (MGCs). This study not only suggests the potential applications of our gel system in biomedical fields, but also provides useful information for the molecular design of short peptide-based hydrogelators with excellent gelation abilities.
Starting Page	3897
Ending Page	3905
Page Count	9
File Format	HTM / HTML PDF
ISSN	1744683X
Volume Number	7
Issue Number	8
Journal	Soft Matter
DOI	10.1039/c0sm01405b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Spectroscopy Bromine Rheology Fluorescence Cytotoxicity Glycine C-terminus Ester Self-assembly Naphthalene Transmission electron microscopy IC50 Library Peptide
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics

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