NDLI: Exploring complex transitions between polymorphs on a small scale by coupling AFM, FTIR and DSC: the case of Irganox 1076® antioxidant

Content Provider	Royal Society of Chemistry (RSC)
Author	Herry, Jean-Marie Saunier, Johanna Marlière, Christian Yagoubi, Najet
Copyright Year	2017
Abstract	This study illustrates the significant interest of using atomic force microscopy (AFM) in force curve imaging mode for discovering and studying not easily detectable solid/solid transitions between polymorphs: we show that AFM in this imaging mode is a powerful means for studying in situ these transitions as they can be (i) detected in a very early step because of the high spatial resolution (at nanometer scale) of AFM and (ii) be distinguished from melting/recrystallization processes that can occur in the same temperature range. This was illustrated with the case of Irganox 1076®. This compound is a phenolic antioxidant currently used in standard polymers; it can bloom on the surface of polymer-based medical devices and its polymorphism might affect the device surface state and thus the biocompatibility. In a previous paper, the polymorphism of this compound was studied: four forms were characterized at a macroscopic level and one of them (form III) was identified on the surface of a polyurethane catheter. However, it was difficult to characterize the transitions between the different forms with only classical tools (DSC, FTIR and SAXS). In the present study, to evidence these transitions, we use AFM measurements coupled with a heating stage and we correlate them to ATR-FTIR measurements and to DSC analysis. This new study put into evidence a solid–solid transition between form III and II.
Starting Page	3804
Ending Page	3818
Page Count	15
File Format	HTM / HTML PDF
ISSN	20462069
Volume Number	7
Issue Number	7
Journal	RSC Advances
DOI	10.1039/c6ra25632e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Classical physics Atomic-force microscopy DSC Polyurethane Granulocyte Crystallization Catheter Nanometre Biocompatibility Single-nucleotide polymorphism Antioxidant Small-angle X-ray scattering
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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