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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Patra, Chitta Ranjan Mukherjee, Sudip Prashanthi, Suthari Bangal, Prakriti Ranjan B, Vinothkumar Sreedhar, Bojja |
| Copyright Year | 2013 |
| Abstract | Synthesis of nanoparticles by a green chemistry approach has seen great attention due to several advantages compared to conventional chemical methods. In this present article we have demonstrated a biosynthetic approach for the fabrication of gold nanobioconjugates (AuNPs-OX) using Olax Scandens leaf extract. The as-synthesized AuNPs-OX have been thoroughly characterized by several physicochemical techniques. The stability of AuNPs-OX was investigated by UV-visible spectroscopy in various physiological solutions. A plausible mechanism for the formation and stabilization of AuNPs-OX has been briefly discussed. Administration of AuNPs-OX to cancer cell lines of lung (A549), breast (MCF-7) and colon (COLO 205) shows the significant inhibition of cancer cell proliferation compared to pristine Olax Scandens leaf extract. Additionally, fluorescence image of A549 cancer cells incubated with AuNPs-OX shows brighter red fluorescence than the cancer cells treated with only Olax leaf extract. Therefore we strongly believe that the green synthesized AuNPs-OX could be used as a “2-in-1 system” for potential application of cancer diagnostics as well as therapeutics in the near future. |
| Starting Page | 2318 |
| Ending Page | 2329 |
| Page Count | 12 |
| File Format | HTM / HTML PDF |
| ISSN | 20462069 |
| Volume Number | 3 |
| Issue Number | 7 |
| Journal | RSC Advances |
| DOI | 10.1039/c2ra22299j |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Ultraviolet\u2013visible spectroscopy Lung cancer MCF-7 Colorectal cancer Fluorescence Green chemistry Olax Scandens Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Chemical Engineering |
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