NDLI: Low level laser therapy alters satellite glial cell expression and reverses nociceptive behavior in rats with neuropathic pain

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Low level laser therapy alters satellite glial cell expression and reverses nociceptive behavior in rats with neuropathic pain

Content Provider	Royal Society of Chemistry (RSC)
Author	Freitas, M. F. Santos, F. M. Bonifácio, R. P. Chacur, M. Oliveira, M. E. Martins, D. O.
Copyright Year	2017
Abstract	Background: Nerve injury often results in persistent or chronic neuropathic pain characterized by spontaneous burning pain accompanied by allodynia and hyperalgesia. Low level laser therapy (LLLT) is a noninvasive method that has proved to be clinically effective in reducing pain sensitivity and consequently in improving the quality of life. Here we examined the effects of LLLT on pain sensitivity induced by chronic constriction injury (CCI) in rats. CCI was performed on adult male rats, subjected thereafter to 10 sessions of LLLT, every other day, and starting 14 days after CCI. Over the treatment period, the animals were evaluated for nociception using behavioral tests, such as allodynia, thermal and mechanical hyperalgesia. Following the sessions, we observed the involvement of satellite glial cells in the dorsal root ganglion (DRG) using immunoblotting and immunofluorescence approaches. In addition we analyzed the expression levels of interleukin 1 (IL-1β) and fractalkine (FKN) after the same stimulus. Results: LLLT induced an early reduction (starting at the second session; p ≤ 0.001) of the mechanical and thermal hyperalgesia and allodynia in CCI rats, which persisted until the last session. Regarding cellular changes, we observed a decrease of GFAP (50%; p ≤ 0.001) expression after LLLT in the ipsilateral DRG when compared with the naive group. We also observed a significant increase of pro-inflammatory cytokines after CCI, whereas LLLT dramatically inhibited the overexpression of these proteins. Conclusions: These data provide evidence that LLLT reverses CCI-induced behavioral hypersensitivity, reduces glial cell activation in the DRG and decreases pro-inflammatory cytokines; we suggest that this involvement of glial cells can be one potential mechanism in such an effect.
Starting Page	547
Ending Page	554
Page Count	8
File Format	HTM / HTML PDF
ISSN	1474905X
Volume Number	16
Issue Number	4
Journal	Photochemical & Photobiological Sciences
DOI	10.1039/c6pp00360e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Allodynia Nociception Western blot Neuroglia Glial fibrillary acidic protein Hypersensitivity CCI Nerve injury LLLT Interleukin 1 beta CX3CL1 Neuropathic pain Hyperalgesia Interleukin-1 family DRG Low level laser therapy Dorsal root ganglion Immunofluorescence
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry

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