Effect of two-week continuous epidural administration of 2% lidocaine on mechanical allodynia induced by spinal nerve ligation in rats.

Content Provider	Europe PMC
Author	Cheong, Yuseon Kim, Minsoo Kim, Namyoong Hwang, Byeongmun
Copyright Year	2020
Abstract	BackgroundLidocaine is an effective against certain types of neuropathic pain. This study aimed to investigate whether timing of initiating continuous epidural infusion of lidocaine affected the glial activation and development of neuropathic pain induced by L5/6 spinal nerve ligation (SNL) in rats.MethodsFollowing L5/6 SNL, rats were epidurally infused 2% lidocaine (drug infusion initiated on days 1, and 7 post SNL model establishment) or saline (saline infusion initiated on day 1 post SNL model establishment) continuously for 14 days. Mechanical allodynia of the hind paw to von Frey filament stimuli was determined prior to surgery, postoperative day 3, and once weekly after SNL model establishment. At 7 days after the infusion of saline or lidocaine ended, spinal activation of proinflammatory cytokines and astrocytes was evaluated immunohistochemically, using antibodies to interleukin-6 (IL-6) and glial fibrillary acidic protein (GFAP).ResultsContinuous epidural administration of 2% lidocaine for 14 days increased the mechanical withdrawal threshold regardless of the difference in timing of initiating lidocaine administration. Epidurally infusing 2% lidocaine inhibited nerve ligation-induced IL-6 and GFAP activation. In the 2% lidocaine infusion group, rats maintained the increased mechanical withdrawal threshold even at 7 days after the discontinuation of 2% lidocaine infusion. ConclusionsContinuous epidural administration of 2% lidocaine inhibited the development of SNL-induced mechanical allodynia and suppressed IL-6 and GFAP activation regardless of the difference in timing of initiating lidocaine administration.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7713833&blobtype=pdf
ISSN	19755171
Journal	Anesthesia and Pain Medicine [Anesth Pain Med (Seoul)]
Volume Number	15
DOI	10.17085/apm.20033
PubMed Central reference number	PMC7713833
Issue Number	3
PubMed reference number	33329833
e-ISSN	23837977
Language	English
Publisher	Korean Society of Anesthesiologists
Publisher Date	2020-07-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © the Korean Society of Anesthesiologists, 2020
Subject Keyword	Anesthetics Glial fibrillary acidic protein Hyperalgesia Interleukin-6 Lidocaine Neuralgia Spinal nerves
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine