NDLI: Mechanical hypersensitivity, sympathetic sprouting, and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain.

Please wait, while we are loading the content...

Year: 2017 Volume: 42

Year: 2016 Volume: 41

Year: 2015 Volume: 40

Year: 2014 Volume: 39

Year: 2013 Volume: 38

Year: 2012 Volume: 37

Year: 2011 Volume: 36

Year: 2011 Volume: 36 Issue: 6

Year: 2011 Volume: 36 Issue: 5

Year: 2011 Volume: 36 Issue: 4

Year: 2011 Volume: 36 Issue: 3

Year: 2011 Volume: 36 Issue: 2

Year: 2011 Volume: 36 Issue: 1

Ultrasound-guided peripheral nerve block in a patient with neurofibromatosis.

Accurate placement of ultrasound-guided lateral popliteal-sciatic perineural catheters.

Injection of injectates is more than just for 'opening the perineural space'.

Continuous femoral nerve block under ultrasound guidance: perineural opening before catheter placement is perhaps no longer necessary.

Ultrasound refraction artifact is unlikely a response to duplication of brachial plexus.

Practical considerations in preparing the pig carcass spine phantom.

Investigation of puncture angles needs clinically defined insertion points.

Specialist's knowledge of local anesthetic systemic toxicity.

Neurologic deficit in conjunction with intraneural injection: more questions than answers.

An unsubstantiated condemnation of intraneural injection.

Intraneural injections.

Recognizing dangerous intraneural injection: is it the musician or the instrument?

Practice advisories by the American Society of Regional Anesthesia and Pain Medicine: grading the evidence and making the grade.

From preemptive to preventive analgesia: time to reconsider the role of perioperative peripheral nerve blocks?

Measured density and calculated baricity of custom-compounded drugs for chronic intrathecal infusion.

Testing haptic sensations for spinal anesthesia.

Computed tomography celiac trunk topography relating to celiac plexus block.

A randomized comparison of infraclavicular and supraclavicular continuous peripheral nerve blocks for postoperative analgesia.

Effect of continuous posttraumatic intrathecal nocistatin on the development of mechanical allodynia.

Use of low-dose steroids in decreasing cytokine release during bilateral total knee replacement.

Lidocaine pretreatment with tourniquet versus lidocaine-propofol admixture for attenuating propofol injection pain: a randomized controlled trial.

Postvoid residuals remain unchanged in patients with postoperative thoracic epidural analgesia after thoracotomy.

Spinal anesthesia for orthopedic surgery: a detailed video assessment of quality.

Mechanical hypersensitivity, sympathetic sprouting, and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain.

Use of a spinal cord stimulator for treatment of Martorell hypertensive ulcer.

Evidence basis for regional anesthesia in multidisciplinary fast-track surgical care pathways.

Year: 2010 Volume: 35

Year: 2009 Volume: 34

Year: 2008 Volume: 33

Year: 2007 Volume: 32

Year: 2005 Volume: 30

Mechanical hypersensitivity, sympathetic sprouting, and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Jing-Yi Xie, Wenrui Strong, Judith A. Guo, Qu-Lian Zhang, Jun-Ming
Description	Country affiliation: China Author Affiliation: Li JY ( Department of Anesthesiology, Xiangya Hospital, Central-South University, Changsha, Hunan, China.)
Abstract	BACKGROUND AND OBJECTIVES: Inflammatory responses in the lumbar dorsal root ganglion (DRG) play a key role in pathologic pain states. Systemic administration of a common anti-inflammatory corticosteroid, triamcinolone acetonide (TA), reduces sympathetic sprouting, mechanical pain behavior, spontaneous bursting activity, and cytokine and nerve growth factor production in the DRG. We hypothesized that systemic TA effects are primarily due to local effects on the DRG. METHODS: Male Sprague-Dawley rats were divided into 4 groups: SNL (tight ligation and transection of spinal nerves) and normal with and without a single dose of TA injectable suspension slowly injected onto the surface of DRG and surrounding region at the time of SNL or sham surgery. Mechanical threshold was tested on postoperative days 1, 3, 5, and 7. Immunohistochemical staining examined tyrosine hydroxylase and glial fibrillary acidic protein in DRG and CD11B antibody (OX-42) in spinal cord. RESULTS: Local TA treatment attenuated mechanical sensitivity, reduced sympathetic sprouting in the DRG, and decreased satellite glia activation in the DRG and microglia activation in the spinal cord after SNL. CONCLUSIONS: A single injection of corticosteroid in the vicinity of the axotomized DRG can mimic many effects of systemic TA, mitigating behavioral and cellular abnormalities induced by spinal nerve ligation. This provides a further rationale for the use of localized steroid injections clinically and provides further support for the idea that localized inflammation at the level of the DRG is an important component of the spinal nerve ligation model, commonly classified as neuropathic pain model.
File Format	HTM / HTML
ISSN	10987339
e-ISSN	15328651
DOI	10.1097/AAP.0b013e318203087f
Journal	Regional Anesthesia and Pain Medicine
Issue Number	1
Volume Number	36
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2011-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neurology Discipline Anesthesiology Adrenal Cortex Hormones Administration & Dosage Ganglia, Spinal Drug Effects Hyperalgesia Prevention & Control Neuralgia Drug Therapy Neuroglia Spinal Nerves Sympathetic Nervous System Triamcinolone Acetonide Analysis Of Variance Animals Antigens, Cd11b Metabolism Disease Models, Animal Physiopathology Glial Fibrillary Acidic Protein Immunohistochemistry Injections Ligation Lumbosacral Region Pain Measurement Rats, Sprague-dawley Surgery Time Factors Tyrosine 3-monooxygenase Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Lidocaine injection into the rat dorsal root ganglion causes neuroinflammation.

Mechanical Hypersensitivity, Sympathetic Sprouting, and Glial Activation Are Attenuated by Local Injection of Corticosteroid Near the Lumbar Ganglion in a Rat Model of Neuropathic Pain

Effect of two-week continuous epidural administration of 2% lidocaine on mechanical allodynia induced by spinal nerve ligation in rats.

Mechanical hypersensitivity, sympathetic sprouting and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain

Spinal cord stimulation reduces mechanical hyperalgesia and glial cell activation in animals with neuropathic pain.

Inhibitory Effects of Scolopendra Pharmacopuncture on the Development and Maintenance of Neuropathic Pain in Rats: Possible Involvement of Spinal Glial Cells.

Effects of glial cell line-derived neurotrophic factor intrathecal injection on spinal dorsal horn glial fibrillary acidic protein expression in a rat model of neuropathic pain.

Pulsed radiofrequency application reduced mechanical hypersensitivity and microglial expression in neuropathic pain model.

The contribution of satellite glial cells to chemotherapy-induced neuropathic pain.

Mechanical hypersensitivity, sympathetic sprouting, and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain.

Similar Documents

Lidocaine injection into the rat dorsal root ganglion causes neuroinflammation.

Mechanical Hypersensitivity, Sympathetic Sprouting, and Glial Activation Are Attenuated by Local Injection of Corticosteroid Near the Lumbar Ganglion in a Rat Model of Neuropathic Pain

Effect of two-week continuous epidural administration of 2% lidocaine on mechanical allodynia induced by spinal nerve ligation in rats.

Mechanical hypersensitivity, sympathetic sprouting and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain

Spinal cord stimulation reduces mechanical hyperalgesia and glial cell activation in animals with neuropathic pain.

Inhibitory Effects of Scolopendra Pharmacopuncture on the Development and Maintenance of Neuropathic Pain in Rats: Possible Involvement of Spinal Glial Cells.

Effects of glial cell line-derived neurotrophic factor intrathecal injection on spinal dorsal horn glial fibrillary acidic protein expression in a rat model of neuropathic pain.

Pulsed radiofrequency application reduced mechanical hypersensitivity and microglial expression in neuropathic pain model.

The contribution of satellite glial cells to chemotherapy-induced neuropathic pain.

Mechanical hypersensitivity, sympathetic sprouting, and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain.