NDLI: Synthesis and bactericidal evaluation of imide N-halamine-loaded PMMA nanoparticles

Content Provider	Royal Society of Chemistry (RSC)
Author	Gao, Yangyang Harnoode, Chokto Cai, Qian Dong, Alideertu Gao, Ge Morigen Dong, Qigeqi Zhang, Shiqi
Copyright Year	2015
Abstract	Imide N-halamine-loaded poly(methyl methacrylate) nanoparticles (PMMA) based on barbituric acid were synthesized as novel antimicrobial agents using radical copolymerization. Evidence for loading imide N-halamine on PMMA nanoparticles has been inferred from different techniques like 1H NMR, FTIR, TEM, SEM, and XPS analyses. The sterilizing effect of the products on bacterial strains was systematically evaluated by selecting Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa as model pathogenic bacteria. The zone of inhibition study and the spread plate technique suggested that the imide N-halamine-loaded PMMA nanoparticles possessed powerful bactericidal activity towards both Gram-positive and Gram-negative bacteria. The effects of contact period, N-halamine structure, particle size, and chlorine content on biocidal efficiency were investigated as well. Long-term stability of the imide N-halamine-loaded PMMA nanoparticles was also confirmed as a function of storage period.
Starting Page	1783
Ending Page	1791
Page Count	9
File Format	HTM / HTML PDF
ISSN	11440546
Volume Number	39
Issue Number	3
Journal	New Journal of Chemistry
DOI	10.1039/c4nj01806k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Antimicrobial Chlorine Escherichia coli Gram-positive bacteria Poly(methyl methacrylate) Bactericide Long-term stability Para-Methoxy-N-methylamphetamine Imide Transmission electron microscopy PMMA Aureus Pseudomonas aeruginosa Bacteria Nuclear magnetic resonance Gram-negative bacteria
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Catalysis

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