NDLI: A mitochondria-targetable fluorescent probe with a large Stokes shift for detecting hydrogen peroxide in aqueous solution and living cells

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A mitochondria-targetable fluorescent probe with a large Stokes shift for detecting hydrogen peroxide in aqueous solution and living cells

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New Journal of Chemistry Vol - 41 Issue - 8

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A mitochondria-targetable fluorescent probe with a large Stokes shift for detecting hydrogen peroxide in aqueous solution and living cells

Content Provider	Royal Society of Chemistry (RSC)
Author	Nie, Jing Meng, Fangfang Niu, Jie Lin, Weiying Liu, Yong
Copyright Year	2017
Abstract	Fluorescent probes with large Stokes shifts play a key role in maintaining the accuracy of biological imaging and minimizing the self-quenching effect. In this work, we have developed a novel fluorescent probe CAI, which possessed a large Stokes shift in various solutions. We found that CAI was capable of detecting hydrogen peroxide (H2O2) in aqueous solution. Furthermore, probe CAI can sense exogenous and endogenous H2O2 in the mitochondria of living RAW 264.7 cells. In addition, probe CAI exhibited ideal properties such as excellent photostability, high sensitivity and selectivity. This fluorescent dye with a large Stokes shift was expected to have a more broad range of applications for developing various fluorescent probes with large Stokes shifts.
Starting Page	3320
Ending Page	3325
Page Count	6
File Format	HTM / HTML PDF
ISSN	11440546
Volume Number	41
Issue Number	9
Journal	New Journal of Chemistry
DOI	10.1039/c7nj00107j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Mitochondrion Dye Stokes shift Stokes Hydrogen peroxide Raw image format CAI
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Catalysis

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